[Untitled]

Authors :: Dieter Weichenhan
Hugo A. Katus
Angelika Bierhaus
Andrew Remppis
Patrick Most
Kai Eggers
Peter P. Nawroth
Johannes Greten
Philipp Ehlermann
Source :: Cardiovascular Diabetology. 5:6
Publication Year :: 2006
Publisher :: Springer Science and Business Media LLC, 2006.
Abstract: Background Atherosclerosis is an inflammatory disease in which a perpetuated activation of NFkappaB via the RAGE (receptor for advanced glycation end products)-MAPK signalling pathway may play an important pathogenetic role. As recently S100 proteins have been identified as ligands of RAGE, we sought to determine the effects of the proinflammatory heterodimer of S100A8/S100A9 on the RAGE-NFkappaB mediated induction of proinflammatory gene expression.

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