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Anti-inflammatory effects of grape seed extract in hemodialysis patients; a pilot study

Authors :
Amir Ghorbanihaghjo
Amirhesam Alirezaei
Alireza Shirzadeh Barough
Siavash Shirzadeh Barough
Hossein Babaie
Abbas Delazar
Tabassom Azizi
Nadereh Rashtchizadeh
Source :
Journal of Renal Injury Prevention. 6:184-187
Publication Year :
2016
Publisher :
Maad Rayan Publishing Company, 2016.

Abstract

Introduction: Immune responses and inflammation are major risk factors for mortality in patients with end-stage renal disease (ESRD). Increased oxidative stress is a common feature of ESRD, and it has been speculated that it is interrelated to inflammation. In many studies it has been proved that red grape seed extract (RGSE) provides an antioxidant efficacy. Objectives: The aim of this study was to investigate the anti-inflammatory effects of RGSE in hemodialysis patients. Patients and Methods: Thirty hemodialysis individuals were divided into two groups that received either 200 mg/day of the RGSE or placebo for one month. Mean ± SD of age of patients was 58.5 ± 10.5 years. Duration of dialysis was 4 ± 3.4 years and 27 patients were male and 3 patients were female. After a 2-week washout period, the groups were crossed over for another one month. Markers of inflammation, lipid profiles and blood factors were measured at baseline after intervention with RGSE or placebo. Results: Our results showed that RGSE consumption could not make statistically significant changes in markers of inflammation, lipid profiles and blood factors in hemodialysis patients. Conclusion: Although RGSE could not improve markers of inflammation, lipid profiles and blood factors in hemodialysis subjects over a 1 month period. However, this result may be due to short period of treatment or low dose of RGSE. Further studies need to clear these contradictions

Details

ISSN :
23452781
Volume :
6
Database :
OpenAIRE
Journal :
Journal of Renal Injury Prevention
Accession number :
edsair.doi...........4c0be4e8fb130ef3497c8a92d4948791
Full Text :
https://doi.org/10.15171/jrip.2017.35