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Anti-inflammatory effects of grape seed extract in hemodialysis patients; a pilot study
- Source :
- Journal of Renal Injury Prevention. 6:184-187
- Publication Year :
- 2016
- Publisher :
- Maad Rayan Publishing Company, 2016.
-
Abstract
- Introduction: Immune responses and inflammation are major risk factors for mortality in patients with end-stage renal disease (ESRD). Increased oxidative stress is a common feature of ESRD, and it has been speculated that it is interrelated to inflammation. In many studies it has been proved that red grape seed extract (RGSE) provides an antioxidant efficacy. Objectives: The aim of this study was to investigate the anti-inflammatory effects of RGSE in hemodialysis patients. Patients and Methods: Thirty hemodialysis individuals were divided into two groups that received either 200 mg/day of the RGSE or placebo for one month. Mean ± SD of age of patients was 58.5 ± 10.5 years. Duration of dialysis was 4 ± 3.4 years and 27 patients were male and 3 patients were female. After a 2-week washout period, the groups were crossed over for another one month. Markers of inflammation, lipid profiles and blood factors were measured at baseline after intervention with RGSE or placebo. Results: Our results showed that RGSE consumption could not make statistically significant changes in markers of inflammation, lipid profiles and blood factors in hemodialysis patients. Conclusion: Although RGSE could not improve markers of inflammation, lipid profiles and blood factors in hemodialysis subjects over a 1 month period. However, this result may be due to short period of treatment or low dose of RGSE. Further studies need to clear these contradictions
- Subjects :
- medicine.medical_specialty
food.ingredient
medicine.drug_class
Urology
medicine.medical_treatment
030232 urology & nephrology
Inflammation
030204 cardiovascular system & hematology
Placebo
medicine.disease_cause
Gastroenterology
Anti-inflammatory
End stage renal disease
03 medical and health sciences
0302 clinical medicine
food
Internal medicine
Medicine
Dialysis
business.industry
Surgery
Nephrology
Grape seed extract
Hemodialysis
medicine.symptom
business
Oxidative stress
Subjects
Details
- ISSN :
- 23452781
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of Renal Injury Prevention
- Accession number :
- edsair.doi...........4c0be4e8fb130ef3497c8a92d4948791
- Full Text :
- https://doi.org/10.15171/jrip.2017.35