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Biological classification of childhood arthritis: roadmap to a molecular nomenclature
- Source :
- Nature Reviews Rheumatology. 17:257-269
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Chronic inflammatory arthritis in childhood is heterogeneous in presentation and course. Most forms exhibit clinical and genetic similarity to arthritis of adult onset, although at least one phenotype might be restricted to children. Nevertheless, paediatric and adult rheumatologists have historically addressed disease classification separately, yielding a juvenile idiopathic arthritis (JIA) nomenclature that exhibits no terminological overlap with adult-onset arthritis. Accumulating clinical, genetic and mechanistic data reveal the critical limitations of this strategy, necessitating a new approach to defining biological categories within JIA. In this Review, we provide an overview of the current evidence for biological subgroups of arthritis in children, delineate forms that seem contiguous with adult-onset arthritis, and consider integrative genetic and bioinformatic strategies to identify discrete entities within inflammatory arthritis across all ages. Childhood-onset arthritis has historically been treated as a separate entity to adult-onset arthritis, with its own nomenclature and classification system. Biological evidence has revealed the limitations of the current approach, necessitating a fresh look at the classification of paediatric arthritis.
- Subjects :
- 030203 arthritis & rheumatology
0301 basic medicine
Childhood arthritis
business.industry
Inflammatory arthritis
Disease classification
Arthritis
Biological classification
medicine.disease
Bioinformatics
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Rheumatology
Genetic similarity
medicine
Biological evidence
business
Nomenclature
Subjects
Details
- ISSN :
- 17594804 and 17594790
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Nature Reviews Rheumatology
- Accession number :
- edsair.doi...........4bd38f1171267097e2b6907f2bd95340