ChemInform Abstract: Synthesis, Antitubercular and Antimicrobial Activity of Some New N-Aryl-1,4-dihydropyridines Containing Furan Nucleus

A wide range of biological activities are associated with 1,4-dihydropyridines Individually or in combination. The synthesis of N-aryl-2,6-dimethyl-3,5-dicarbmethoxy-4-[5'-(m-chloro-p-flourophenyl)-2'-furyl]-1,4-dihydropyridines (6a-J) and N-aryl-2,6-dimethyl-3,5-dicarbmethoxy-4-[5'-(m-chloro-p-flourophenyl)-2'-furyl]-1,4-dihydropyrldines (7a-j) was under-taken with hope that they may be biologically active molecules with improved activity, less toxicity and undesirable side effects. The newly synthesized compounds were characterized on the basis of elemental analysis, IR, 1 H NMR and mass spectral data. All newly synthesized compounds were tested for their antitubercular activity against Mycobacterium tuberculosis H 37 RV ATCC 27294, antibacterial activity against different Gram +ve and Gram -ve bacteria and antifungal activity.