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Simultaneous EGFR mutation detection and copy number assessment in circulating tumour DNA (ctDNA) to inform molecular methods of therapy resistance and plasma ctDNA content in lung adenocarcinoma

Authors :
Mary O'Brien
Jaishree Bhosle
Sanjay Popat
David Gonzalez
Sareena Rana
Julian Downward
Nicholas C. Turner
Ros Cutts
Alexandra Pender
Isaac Garcia-Murillas
Source :
Journal of Clinical Oncology. 34:e23027-e23027
Publication Year :
2016
Publisher :
American Society of Clinical Oncology (ASCO), 2016.

Abstract

e23027Background: EGFR circulating tumour DNA (ctDNA) is a dynamic blood-borne marker predictive of EGFR tyrosine kinase inhibitor treatment response and disease progression. Microdroplet digital P...

Details

ISSN :
15277755 and 0732183X
Volume :
34
Database :
OpenAIRE
Journal :
Journal of Clinical Oncology
Accession number :
edsair.doi...........4bb08f5d7409a691b66ce371b94e3b8e
Full Text :
https://doi.org/10.1200/jco.2016.34.15_suppl.e23027