Back to Search
Start Over
Topical Application of Tacrolimus Ointment Did Not Alter the Cutaneous Pigmentation of Yucatan Micropigs
- Source :
- International Journal of Toxicology. 18:19-22
- Publication Year :
- 1999
- Publisher :
- SAGE Publications, 1999.
-
Abstract
- Tacrolimus is a potent immunosuppressant marketed for the prevention of rejection in liver and kidney transplantation. Topical tacrolimus has been shown to be effective in the treatment of atopic dermatitis, a disease with an immunologic basis, and is currently being developed for this indication. The objective of the current study was to determine whether repeated topical application of tacrolimus ointment could result in hypopigmentation at the application site(s). Each of 10 Yucatan miniature pigs received topical application of 0.03%, 0.1%, and 0.3% tacrolimus ointment, positive control (a combination of 2% 4-hydroxyanisole and 0.01% all-trans-retinoic acid, 4-HAArRA), and a negative control (vehicle placebo) to five test sites (approximately 12.5 cm2) along either side of the dorsal midline (10 sites per animal). Tacrolimus and controls were randomly assigned to the test site on each animal and were applied unoccluded twice daily for 8 weeks at a dose volume of 0.1 ml per site for tacrolimus and vehicle control and 0.025 ml per site for the positive control. Topical application of tacrolimus ointment in concentrations of up to 0.3% for 8 weeks had no effect on the cutaneous pigmentation of Yucatan miniature swine. In contrast, the application of 4-HAArRA produced a statistically significant (P
- Subjects :
- medicine.medical_specialty
Test site
business.industry
Atopic dermatitis
010501 environmental sciences
Toxicology
medicine.disease
Placebo
030226 pharmacology & pharmacy
01 natural sciences
Dermatology
Tacrolimus
Transplantation
03 medical and health sciences
surgical procedures, operative
0302 clinical medicine
Depigmentation
Toxicity
Medicine
medicine.symptom
business
0105 earth and related environmental sciences
Hypopigmentation
Subjects
Details
- ISSN :
- 1092874X and 10915818
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- International Journal of Toxicology
- Accession number :
- edsair.doi...........4ba6d656cd6d9e848c4f810b7a4388f6