Back to Search Start Over

DNA damage: a histone-code mediator leaves the stage

Authors :
Jiri Lukas
Jiri Bartek
Source :
Nature Structural & Molecular Biology. 15:430-432
Publication Year :
2008
Publisher :
Springer Science and Business Media LLC, 2008.

Abstract

Chromosomal breaks destabilize the genome and can cause developmental defects and diseases such as cancer. New work suggests that, shortly after DNA damage, dissociation of the histone binding protein HP1β from chromatin facilitates restoration of genome integrity.

Subjects

Subjects :
Mediator
Genome integrity
Structural Biology
DNA damage
Histone binding protein
Histone code
Chromosomal Breaks
Biology
Molecular Biology
Genome
Chromatin
Cell biology

Details

ISSN :
15459985 and 15459993
Volume :
15
Database :
OpenAIRE
Journal :
Nature Structural & Molecular Biology
Accession number :
edsair.doi...........4b0e0dfdc874f7ab612592e20b998a87
Full Text :
https://doi.org/10.1038/nsmb0508-430
Full Text Access
View/download PDF

Tools

Authors Abstract Subjects Details