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Mutated Ephrin Receptor Genes in Non-Small Cell Lung Carcinoma and Their Occurrence with Driver Mutations-Targeted Resequencing Study on Formalin-Fixed, Paraffin-Embedded Tumor Material of 81 Patients
- Source :
- Genes, Chromosomes and Cancer. 52:1141-1149
- Publication Year :
- 2013
- Publisher :
- Wiley, 2013.
-
Abstract
- Non-small cell lung carcinoma (NSCLC) is the most common subtype of lung cancer. The oncogenic potential of receptor tyrosine kinases (RTKs) is widely known and they are potential targets for tailored therapy. Ephrin receptors (Ephs) form the largest group of RTKs. Nevertheless, Ephs are not widely studied in NSCLC so far. The aim of our study was to investigate novel mutations of Eph genes (EPHA1–8, EPHB1–4, EPHB6) and their association with clinically relevant mutations in BRAF, EML4-ALK, EGFR, INSR, KDR, KRAS, MET, PDGFRA, PDGFRB, PIK3, PTEN, RET, and TP53 in NSCLC patients. Targeted resequencing was conducted on 81 formalin-fixed, paraffin-embedded NSCLC tumor specimens. We analyzed missense and nonsense mutations harbored in the coding regions of the selected genes. We found 18 novel mutations of Ephs in 20% (16 of 81) of the patients. Nearly half of these mutations occurred in the protein kinase domain. The mutations were not mutually exclusive with other clinically relevant mutations. Our study shows that Ephs are frequently mutated in NSCLC patients, and occur together with other known mutations relevant to the pathogenicity of NSCLC. © 2013 Wiley Periodicals, Inc.
- Subjects :
- Cancer Research
PDGFRB
PDGFRA
Bioinformatics
medicine.disease_cause
03 medical and health sciences
0302 clinical medicine
Genetics
EPHB6
medicine
PTEN
Lung cancer
neoplasms
030304 developmental biology
0303 health sciences
biology
Crizotinib
Erythropoietin-producing hepatocellular (Eph) receptor
medicine.disease
respiratory tract diseases
3. Good health
030220 oncology & carcinogenesis
Cancer research
biology.protein
KRAS
medicine.drug
Subjects
Details
- ISSN :
- 10452257
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Genes, Chromosomes and Cancer
- Accession number :
- edsair.doi...........4a275438e6a605feae8754f83e770b6f