Probing renal ischemia reperfusion-induced cardiac hypertrophy by a Raman spectroscopy

Renal failure is characterized by systemic inflammation that affects directly some organs like liver, lung and heart. Patients with renal insufficiency have a higher risk for developing cardiovascular diseases, representing 45% of the causes of death in patients undergoing hemodialysis. It is reported that unilateral renal ischemia/reperfusion is able to generate renal lesion, followed by systemic sterile inflammation, resulting in development of cardiac remodeling and hypertrophy. Considering that, the focus of this study was to investigate the cardiac remodeling induced by renal ischemia/reperfusion protocol using Fourier-Transform Raman Spectroscopy (FT-Raman) to probe molecular changes in mice.