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Synthesis and antiviral evaluation of novel N-6 substituted adenosine analogues
- Source :
- Tetrahedron Letters. 58:190-193
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- A series of adenosine analogues were synthesized and their biological evaluation was tested against Coxsackie virus B3 (CVB3) and Herpes simplex virus type 1(HSV-1) in HEp-2 cells. The hydrophobic constant, acute toxicity, carcinogenicity and mutagenicity were calculated. Analogues with piperazine derivatives 8b showed promising activities against CVB3 with a lower IC 50 value and higher selectivity index, their efficacy was better than that of the commercialized medicine, Ribavirin. These described adenosine analogues exhibit potent antiviral activities against several viruses, and offer new leads for further development.
- Subjects :
- 0301 basic medicine
010405 organic chemistry
Chemistry
Stereochemistry
viruses
Ribavirin
Organic Chemistry
medicine.disease_cause
01 natural sciences
Biochemistry
Adenosine
Acute toxicity
Virus
0104 chemical sciences
03 medical and health sciences
Piperazine
chemistry.chemical_compound
030104 developmental biology
Herpes simplex virus
Drug Discovery
medicine
Selectivity
Carcinogen
medicine.drug
Subjects
Details
- ISSN :
- 00404039
- Volume :
- 58
- Database :
- OpenAIRE
- Journal :
- Tetrahedron Letters
- Accession number :
- edsair.doi...........498dfbd5b8346979b2eb62758bf06e6e