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Acquired Resistance to Schistosoma japonicum in IgE-Deficient SJA/9 Mice Immunized with Irradiated Cercariae
- Source :
- International Archives of Allergy and Immunology. 102:191-194
- Publication Year :
- 1993
- Publisher :
- S. Karger AG, 1993.
-
Abstract
- Participation of IgE in protective immunity against Schistosoma japonicum was examined by comparing congenital IgE-deficient SJA/9 and IgE-producing SJL/J mice. Mice immunized with 100 irradiated cercariae 7 weeks previously were infected with 50 live cercariae. In SJL/J mice at 40 days after infection, a 3-to 4-fold increase of total IgE levels and anti-S, japonicum egg IgE antibody production were observed with no significant difference between immunized and nonimmunized mice. IgE was not detected in SJA/9 mice throughout the experiments. Protective immunity evaluated by recovery of adult worms was found in SJA/9 mice and was comparable to that of SJL/J mice. These results suggest that acquired immunity in mice with irradiated cercariae of S. japonicum was not dependent on IgE in these strains of mice.
Details
- ISSN :
- 14230097 and 10182438
- Volume :
- 102
- Database :
- OpenAIRE
- Journal :
- International Archives of Allergy and Immunology
- Accession number :
- edsair.doi...........492f8fd2681b894e331f0bb40b9148e0