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‘Click’ to bidentate bis-triazolyl sugar derivatives with promising biological and optical features
- Source :
- Tetrahedron Letters. 52:894-898
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- Bidentate 1-O-methyl-α- d -pyranoglucosides bearing two triazolyl α-ketoester groups on the 2,6- or 3,4-positions of sugar scaffold were efficiently synthesized via Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (click reaction) in good yields. These newly featured sugar derivatives displayed favorable inhibitory activity on protein tyrosine phosphatase 1B (PTP1B) and unexpected selective fluorescence quenching in the presence of Ni2+.
Details
- ISSN :
- 00404039
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Tetrahedron Letters
- Accession number :
- edsair.doi...........49047ea54eef8e52cdff7052d7e5796c