Combination therapy for multidrug-resistant cytomegalovirus disease

Authors :: Halter, J.
Stüssi, G.
Weisser, M.
Dumoulin, A.
Battegay, M.
Passweg, J.
Kalberer, C.
Dirks, J.
Stuehler, C.
Nowakowska, J.
Hirsch, H.H.
Schibli, A.
Khanna, N.
Heim, D.
Bucher, C.
Rovó, Alicia
Publication Year :: 2015
Publisher :: Wiley, 2015.
Abstract: Multidrug-resistant (MDR) cytomegalovirus (CMV) emerged after transient responses to ganciclovir, foscarnet, and cidofovir in a CMV-seropositive recipient who underwent allogeneic hematopoietic stem cell transplantation from a CMV-seronegative donor. Experimental treatments using leflunomide and artesunate failed. Re-transplantation from a CMV-seropositive donor supported by adoptive transfer of pp65-specific T cells and maribavir was followed by lasting suppression. This case illustrates that successful MDR CMV therapy may require individualized multidisciplinary approaches. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.