Synthesis and conformational analysis of 2-methylthioderivatives of 1-(2'-furyl)ethanol and their -methyl derivatives

The synthesis and conformational analysis of some β-thioderivatives of 1-(2'-furyl)ethanol and their O -methyl derivatives, Ar-CHX-CH2-Y (X: OH and OMe; Y: SMe, SOMe and SO2Me), are reported. The conformational equilibria have been established from 1H-nmr data and high dilution ir studies. Immunosuppressive properties of (methylsulphinyl)methyl 2-furyl ketone and 2-(methylsulphinyl)-1-(2'-furyl)ethanol, (RR/SS) and (RS/SR), have been tested.