Synthesis and testing of substituted phenylthioribose analogs against Klebsiella pneumoniae

Halogen substituted analogs of 5-(phenylthio)ribose were synthesized and tested as inhibitors of the methylthioribose kinase-containing pathogen. Klebsiella pneumoniae . All of the compounds exhibit good activity against organism. 5-(4-Iodophenylthio)ribose demonstrated the most potent inhibitory effects with a 50% inhibitory concentration (IC 50 ) value of ′ 2.5 picomolar (0.0009 ng/ml).