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Drug Induced Autoimmunity Related Neutrophilic Dermatosis by Calcium Channel Blockers
- Source :
- SKIN The Journal of Cutaneous Medicine. 3:431-434
- Publication Year :
- 2019
- Publisher :
- National Society for Cutaneous Medicine, 2019.
-
Abstract
- Autoimmunity Related Neutrophilic Dermatoses (ARND) is a recently described entity characterized by urticarial papules and plaques with histology showing a neutrophilic perivascular and interstitial infiltrates with leukocytoclasis, along with variable vacuolar interface dermatitis. We report a 38 year old Caucasian female with a ten year history of lupus who presented with pruritic urticarial papules and plaques on the face, trunk, upper extremities and thighs. The onset occurred 10 days after she started a calcium channel blocker (CCB), diltiazem. Histopathology revealed scattered dyskeratotic keratinocytes, vacuolar interface dermatitis, and a sparse perivascular and interstitial mixed infiltrate of neutrophils within the dermis. There was focal leukocytoclasis, dermal edema, and rare eosinophils. The patient initially improved with prednisone taper, but flared again upon starting a different CCB, verapamil. Exposure to certain medications such as CCB in the setting of autoimmune connective tissue disorder may be the inciting trigger for a neutrophilic dermatoses. Future studies may provide further information on the pathogenesis of ARND and cutaneous drug eruption in the setting of SLE.
- Subjects :
- medicine.medical_specialty
Systemic lupus erythematosus
medicine.drug_class
business.industry
Calcium channel blocker
medicine.disease_cause
medicine.disease
Dermatology
Autoimmunity
Drug eruption
Pathogenesis
medicine.anatomical_structure
Dermis
Prednisone
medicine
Histopathology
business
medicine.drug
Subjects
Details
- ISSN :
- 25741624
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- SKIN The Journal of Cutaneous Medicine
- Accession number :
- edsair.doi...........4864d61d802cf05c98909b9c7ea5b4c9