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Application of Gold Nanoparticles for Early Detection of Breast Cancer Cells
- Source :
- e-Journal of Surface Science and Nanotechnology. 9:544-547
- Publication Year :
- 2011
- Publisher :
- Surface Science Society Japan, 2011.
-
Abstract
- Gold nanoparticles (GNPs) have been synthesized by a chemical reduction method using sodium borohydride and functionalized with amino groups on their surface. The GNPs were then conjugated with the anti-HER2 human antibody (trastuzumab) for detecting breast cancer cells. The specific binding of trastuzumab-conjugated GNPs onto the breast cancer cells (KPL4 line) were observed by bright-field and dark-field microscopy and were for the first time observed by scanning electron microscopy and energy dispersive X-ray scanning. [DOI: 10.1380/ejssnt.2011.544]
- Subjects :
- Materials science
biology
Scanning electron microscope
Bioengineering
Nanotechnology
Surfaces and Interfaces
Conjugated system
Condensed Matter Physics
Surfaces, Coatings and Films
Sodium borohydride
chemistry.chemical_compound
chemistry
Mechanics of Materials
Trastuzumab
Colloidal gold
Microscopy
medicine
biology.protein
Breast cancer cells
Antibody
skin and connective tissue diseases
Biotechnology
medicine.drug
Nuclear chemistry
Subjects
Details
- ISSN :
- 13480391
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- e-Journal of Surface Science and Nanotechnology
- Accession number :
- edsair.doi...........48468ee162bb34f81519d1233317d252