953-P: Glycated Albumin Is Not an Accurate Marker of Glycemia in Pregnancy or Postpartum

Objective: Assessments for diabetes are vital to pregnancy and postpartum (PP) care, but screening, conducted with oral glucose tolerance tests (OGTTs), is cumbersome. Outside of pregnancy, percent glycated albumin (%GAlb) reflects average glycemia over a period of weeks. %GAlb may not be subject to the same limitations as hemoglobin A1c in pregnancy, as it does not rely on stable red blood cell kinetics. We studied %GAlb as a potential glycemic marker during gestation and PP. Study Design: Pregnant women (N=50) in the Study of Pregnancy Regulation of Insulin and Glucose cohort underwent 75g OGTTs at a mean of 13 weeks (SD 1.6, V1) and 26 weeks (SD 1.4, V2) of gestation and 11 weeks (SD 4.9) PP. Non-pregnant controls had a single OGTT. We measured GAlb on frozen plasma samples. Results: Serum total GAlb and total albumin decreased from V1 to V2 and increased PP to levels higher than at V1. %GAlb declined between V1 and V2 (β= -0.64 95% CI [-0.8, -0.4] p Conclusions: %GAlb decreases during gestation and remains decreased PP, despite a return of total albumin and total GAlb to baseline. Given the lack of correlation with OGTT glucose levels or hemoglobin A1c, %GAlb is unlikely to be useful in assessing glycemia in pregnant or PP women. Disclosure M. D. Soffer: None. K. James: None. M. J. Callahan: None. W. H. Barth: None. C. E. Powe: None.