Ein Beitrag zur Feinstruktur von endokrin aktiven Epithelkörpercarcinomen

The fine structure of a parathyroid carcinoma of high endocrine activity is described and compared to adenomas. There are some striking features especially concerning the Golgi apparatus. Non-membrane bound fine granular material and vesicles engulfing cytoplasmatic ground substance are seen at the outer surface of the Golgi stacks. A GERL like reticulum was observed with production of coated vesicles and dense bodies. Condensing vacuoles or prosecretory granules could never be demonstrated in the area of the Golgi complex. A smooth reticulum like network with an electron dense core connecting Golgi apparatus and granular endoplasmatic reticulum was shown to be present in about all cancer cells. This smooth reticulum is producing secretory granules by budding off, apparently taking over the function of the condensing vacuoles of the Golgi apparatus.