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A chemo-mechanical model for the single myofibril in striated muscle contraction
- Source :
- Meccanica. 52:3357-3369
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Based on the framework of sliding-filament theory and on the cross-bridges dynamics, a mathematical model for the simulation of the force response and length change of individual myofibril is presented. The myofibril is modeled as a group of segments placed in series, each segment represents a half-sarcomere with active and elastic properties. A multiple-state cross-bridge formalism relates the half Sarcomere force to the chemical kinetics of ATP hydrolysis. The corresponding system of nonlinear nonlocal partial differential equations of the model is analyzed. A numerical approach is introduced and some numerical tests are performed. The proposed in-silico model enables the study of biologically relevant process in the muscle contraction process, also in the case of muscular diseases, with reasonable computational effort.
- Subjects :
- 0301 basic medicine
Physics
Partial differential equation
Chemo mechanical
Quantitative Biology::Tissues and Organs
Mechanical Engineering
Nanotechnology
Striated muscle contraction
Mechanics
Condensed Matter Physics
Sarcomere
Quantitative Biology::Subcellular Processes
03 medical and health sciences
Nonlinear system
030104 developmental biology
0302 clinical medicine
Mechanics of Materials
ATP hydrolysis
medicine
medicine.symptom
Myofibril
030217 neurology & neurosurgery
Muscle contraction
Subjects
Details
- ISSN :
- 15729648 and 00256455
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Meccanica
- Accession number :
- edsair.doi...........478af43168df41e696dce5b19a4e846b