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A phase 1 study of PF-05082566 (anti-4-1BB) in patients with advanced cancer

Authors :
Craig Davis
Nancy L. Bartlett
Neil H. Segal
Bo Huang
Michael J. Pishvaian
Roch Houot
Paul Nghiem
Holbrook E Kohrt
Ganesh Mugundu
Ronald Levy
Ajay K. Gopal
Stephanie Anne Kronenberg
Shailender Bhatia
Aron Thall
Source :
Journal of Clinical Oncology. 32:3007-3007
Publication Year :
2014
Publisher :
American Society of Clinical Oncology (ASCO), 2014.

Abstract

3007 Background: 4-1BB agonists markedly enhance cytotoxic T-cell responses, resulting in anti-tumor activity in several models. PF-05082566 is a fully humanized IgG2 agonist monoclonal antibody ta...

Details

ISSN :
15277755 and 0732183X
Volume :
32
Database :
OpenAIRE
Journal :
Journal of Clinical Oncology
Accession number :
edsair.doi...........476846fdc2f6458b15f4f9e408e43ebf
Full Text :
https://doi.org/10.1200/jco.2014.32.15_suppl.3007