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Réabsorption du sel et sécrétion du potassium par le néphron distal
- Source :
- médecine/sciences. 32:274-280
- Publication Year :
- 2016
- Publisher :
- EDP Sciences, 2016.
-
Abstract
- The study of Familial Hyperkalemic Hypertension (FHHt), a rare monogenic disease, allowed remarkable advances in the understanding of the mechanisms of regulation of NaCl reabsorption by the distal nephron. FHHt results from mutations in the genes encoding WNK1 and WNK4, two serine-threonine kinases of the WNK (With No lysine [K]) family. The clinical manifestations of FHHt are due, among others, to an increased activity of the Na(+)-Cl(-) cotransporter NCC. Several groups therefore tried to understand how WNK1 and WNK4 could regulate NCC. However, the data were often contradictory. Two of our recent studies allowed to partially explain these controversies and to propose a new model for the regulation of NCC by the WNKs.
- Subjects :
- 0301 basic medicine
Protein-Serine-Threonine Kinases
urogenital system
Reabsorption
Kinase
General Medicine
Biology
WNK1
Distal nephron
Monogenic disease
Molecular biology
General Biochemistry, Genetics and Molecular Biology
WNK4
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Cotransporter
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 19585381 and 07670974
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- médecine/sciences
- Accession number :
- edsair.doi...........4737a9eb7348f17baf75c15596c0f5b1