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Chronic effects of venlafaxine on synaptophysin and neuronal cell adhesion molecule in the hippocampus of cerebral ischemic miceThis paper is one of a selection of papers published in this special issue entitled 'Second International Symposium on Recent Advances in Basic, Clinical, and Social Medicine' and has undergone the Journal's usual peer review process
- Source :
- Biochemistry and Cell Biology. 88:655-663
- Publication Year :
- 2010
- Publisher :
- Canadian Science Publishing, 2010.
-
Abstract
- Venlafaxine, a novel antidepressant, inhibits serontonin and norepinephrine reuptake in the presynaptic cleft. Unlike typical selective serontonin reuptake inhibitors (SSRIs), venlafaxine may have modulatory effects on nerve terminals and neuronal plasticity. Our preliminary data found that 5 mg·kg–1·d–1 of venlafaxine treatment prevented decreased synaptophysin (SYP) in the hippocampus, which results from chronic restrained stress in the rat model. The present study investigates whether venlafaxine regulates alterations of synaptophysin and neuronal cell adhesion molecule (NCAM) in a post-stroke depression mouse model. We compared the expression level of SYP and NCAM in the hippocampus of global cerebral ischemic (GCI) mice treated with different doses of venlafaxine using immunohistological and Western blot analysis. Pre-treatment with intraperitoneal injection of venlafaxine (2.5 and 5.0 mg·kg–1·d–1) for 14 days significantly prevented the decrease of SYP in the hilus area of the hippocampus in vehicle-treated GCI mice. NCAM was significantly higher in the hippocampus of vehicle-treated GCI mice, and pretreatment with venlafaxine prevented alterations of NCAM, with the high-dose venlafaxine group comparable with vehicle-sham mice. The results suggest the alteration of neuronal remodeling proteins in the hippocampus may be an underlying mechanism of venlafaxine in treating post-stroke depression.
- Subjects :
- medicine.medical_specialty
biology
business.industry
Venlafaxine Hydrochloride
Hippocampus
Venlafaxine
Cell Biology
Biochemistry
Endocrinology
nervous system
Internal medicine
medicine
Synaptophysin
biology.protein
Antidepressant
Neural cell adhesion molecule
business
Reuptake inhibitor
Molecular Biology
Neuronal Cell Adhesion Molecule
medicine.drug
Subjects
Details
- ISSN :
- 12086002 and 08298211
- Volume :
- 88
- Database :
- OpenAIRE
- Journal :
- Biochemistry and Cell Biology
- Accession number :
- edsair.doi...........472e6a7b572425c7faf093abe8fa96d6