Non-peptide fibrinogen receptor antagonists. 21. The synthesis of [3H]L-738,167

The synthesis of [3H]L-756,568, an orally active fibrinogen receptor antagonist, is described. Two synthetic pathways were developed using either bromoindoles 2a/2b or bromoaryl sufonamide 11 as the precursor. Use of the bromoaryl sulfonamide precursor led to [3H]L-756,568 with higher radiochemical purity, higher radiochemical yield, and slightly higher specific activity. Copyright © 1999 John Wiley & Sons, Ltd.