Participation of serotoninmodulated anticonsolidation protein in mediation of action of adverse factors on lipid peroxidation level in tissues of sturgeon fry Acipenser güldenstädti persicus

The work analyzes participation of the serotoninergic system in correction of adverse effects of benthic deposits contaminated with industrial wastes on the level of lipid peroxidation (LPO) in the fry of the sturgeon Acipenser guldenstadti persicus. In the first series of the study, two intramuscular injections to the sturgeon fry of serotonin-modulated anticonsolidation protein (SMAP) that is in the direct correlation with the serotonin level led to pronounced normalization in the animal tissues of the LPO level whose increase was due to keeping the sturgeons in the fresh water contaminated with benthic deposits. In the second series of the study, administration to the animals of polyclonal anti-SMAP antibodies led to a significant increase of the LPO level in the tissues, similar to effects of the benthic deposits. It is concluded that adverse factors can produce their negative pro-oxidative effects on the organism tissues through a decrease of activity of the serotoninergic system, whereas an artificial increase of the serotoninergic system activity promotes correction of the oxidative stress.