Treatment Outcomes and Prognostic Factors in Patients with Low-Grade Glioma

Low-grade gliomas are responsible for approximately 15% of all adult primary intracranial tumors. The treatment strategy is still controversial. In this study, we aimed to evaluate the treatment outcomes and predictive factors for local control and overall survival in this population. We have reviewed 50 cases of adult patients with low-grade gliomas diagnosed from 2009 to 2019. All patients underwent surgical intervention followed by post-operative radiotherapy, and some also received chemotherapy. With a median follow-up of 21 months for surviving patients, the 2-year overall and progression-free survival rates were 83 and 82%, respectively. Only the different radiotherapy methods showed independent prognostic values for overall survival and disease-free survival of our patients. In this study, we found that only type of radiotherapy (2D vs. 3D) has prognostic value for 2-year PFS and overall survival rates. There need to be further efforts to optimize radiotherapy techniques and to integrate new therapeutic modalities.