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Hematopoietic Cell Transplantation in the Treatment of Newly Diagnosed Adult Acute Myeloid Leukemia: An Evidence-Based Review from the American Society of Transplantation and Cellular Therapy
- Source :
- Transplantation and Cellular Therapy. 27:6-20
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- The role of hematopoietic cell transplantation (HCT) in the management of newly diagnosed adult acute myeloid leukemia (AML) is reviewed and critically evaluated in this evidence-based review. An AML expert panel, consisting of both transplant and nontransplant experts, was invited to develop clinically relevant frequently asked questions covering disease- and HCT-related topics. A systematic literature review was conducted to generate core recommendations that were graded based on the quality and strength of underlying evidence based on the standardized criteria established by the American Society of Transplantation and Cellular Therapy Steering Committee for evidence-based reviews. Allogeneic HCT offers a survival benefit in patients with intermediate- and high-risk AML and is currently a part of standard clinical care. We recommend the preferential use of myeloablative conditioning in eligible patients. A haploidentical related donor marrow graft is preferred over a cord blood unit in the absence of a fully HLA-matched donor. The evolving role of allogeneic HCT in the context of measurable residual disease monitoring and recent therapeutic advances in AML with regards to maintenance therapy after HCT are also discussed.
- Subjects :
- Oncology
medicine.medical_specialty
Context (language use)
Cell therapy
03 medical and health sciences
0302 clinical medicine
Maintenance therapy
hemic and lymphatic diseases
Internal medicine
medicine
Immunology and Allergy
Transplantation
business.industry
Adult Acute Myeloid Leukemia
Cell Biology
Hematology
medicine.disease
surgical procedures, operative
Systematic review
Graft-versus-host disease
030220 oncology & carcinogenesis
Cord blood
Molecular Medicine
business
030215 immunology
Subjects
Details
- ISSN :
- 26666367
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Transplantation and Cellular Therapy
- Accession number :
- edsair.doi...........46483fb1597317a2e073f784d0160001