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Metabolic Status and Reaction to Heat of Normal and Tumor Tissue

Authors :
P. W. Vaupel
D. K. Kelleher
Source :
Thermoradiotherapy and Thermochemotherapy ISBN: 9783642633829
Publication Year :
1995
Publisher :
Springer Berlin Heidelberg, 1995.

Abstract

The occurrence of differential heating and differential thermal sensitivity between malignant tumors and normal tissues is thought to be due to limited heat dissipation and energy depletion in many solid tumors which in turn results from an inadequately functioning tumor microcirculation (Jain and Ward-Hartley 1984; Song 1984, 1991; Vaupel and Kallinowski 1987; Reinhold 1988; Vaupel et al. 1988a; Vaupel 1990). As a consequence of the latter pathophysiological condition, supply and drainage function are restricted in many solid tumors or, at least, in some tumor areas, thus creating a hostile metabolic microenvironment characterized by tissue hypoxia, acidosis, and energy depletion. Thermal sensitivity has been shown to depend greatly on tumor pH, and on energy and nutritional status of the tumors treated. Although no conclusive evidence is so far available concerning the ranking of these pivotal factors, there is no doubt that the rate and homogeneity of blood perfusion plays a paramount role in determining the metabolic and energy status.

Details

ISBN :
978-3-642-63382-9
ISBNs :
9783642633829
Database :
OpenAIRE
Journal :
Thermoradiotherapy and Thermochemotherapy ISBN: 9783642633829
Accession number :
edsair.doi...........464034ddfbad85ec5398a94268f3cd2c
Full Text :
https://doi.org/10.1007/978-3-642-57858-8_8