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Authors :
Erzsébet Szepesi
Mihály Kata
Csaba Zoltán Novák
Szilvia Berkó
Géza Regdon
Zoltán Aigner
Source :
Journal of Inclusion Phenomena and Macrocyclic Chemistry. 42:219-226
Publication Year :
2002
Publisher :
Springer Science and Business Media LLC, 2002.

Abstract

Cyclodextrin complexation was applied to achieve better aqueous solubility of the drug and to formulate suppositories. Binary products were prepared in several mole ratios by two different methods. The dissolution profiles and in vitro membrane diffusion behaviour of the compositions were investigated. Thermoanalytical studies were performed in order to confirm inclusion complex formation. Compositions were selected for further detailed investigations and for incorporation into suppository dosage form.

Details

ISSN :
09230750
Volume :
42
Database :
OpenAIRE
Journal :
Journal of Inclusion Phenomena and Macrocyclic Chemistry
Accession number :
edsair.doi...........460211613c4be970964c6ac191ef7b8e