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Prospective Evaluation of Terminal Ileitis in a Surveillance Population of Patients with Ulcerative Colitis
- Source :
- Inflammatory Bowel Diseases. 22:2448-2455
- Publication Year :
- 2016
- Publisher :
- Oxford University Press (OUP), 2016.
-
Abstract
- BACKGROUND Ulcerative colitis (UC) is a disease that is normally limited to involvement of the colon. Terminal ileitis in patients with UC with only inactive or mildly active disease has never been investigated. The aim of this prospective study was to determine the prevalence and significance of ileitis among patients with UC enrolled in an endoscopic surveillance program. METHODS The study consisted of 72 patients with UC and 90 healthy controls who underwent surveillance and screening colonoscopy, respectively. The endoscopic and histologic features of the terminal ileum (both groups) and colon (UC group only) were evaluated in a standardized fashion. Extensive clinical and endoscopic information was obtained from the subjects, and these data were compared between patients with UC either with or without ileitis. RESULTS Sixteen of 72 patients with UC (22%) had ileitis compared to only 4 of 90 (4%) of the non-UC controls (P < 0.001). None of the patients had features of backwash. Among patients with UC, the presence of ileitis showed a trend towards correlation with extent of disease, but a significant association with involvement of the colonic side of the ileocecal valve (P = 0.02) was noted. Alcohol use in the week before the colonoscopy was also significant (P = 0.02). There were no other features that were significantly related to ileitis in the patients with UC. Only one UC case with ileitis developed Crohn's disease on follow-up. CONCLUSIONS Ileitis in patients with UC may represent a primary extracolonic manifestation of UC in patients with inactive or mild disease and is not due to backwash.
- Subjects :
- medicine.medical_specialty
education.field_of_study
medicine.diagnostic_test
business.industry
Population
Gastroenterology
Case-control study
Colonoscopy
medicine.disease
Ulcerative colitis
03 medical and health sciences
Ileocecal valve
0302 clinical medicine
medicine.anatomical_structure
030220 oncology & carcinogenesis
Internal medicine
medicine
Immunology and Allergy
030211 gastroenterology & hepatology
Ileitis
Colitis
education
business
Prospective cohort study
Subjects
Details
- ISSN :
- 10780998
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Inflammatory Bowel Diseases
- Accession number :
- edsair.doi...........45791c32a573d1520420f0034cb44669