Antifungal Flavonoids from Ficus sarmentosa var. henryi (King) Corner

The methanol extract of Ficus sarmentosa var. henryi (King) Corner was found to detect potent inhibitory activities against 6 crop pathogenic fungi, Fusarium graminearum, Pumpkin fusarium Wilt, Curvularia lunata (Wakker) Boed, Septoria zeicola Stout, Botrytis cinerea, and Rhizoctonia solani. Four flavonoids were isolated from the extract of F. sarmentosa var. henryi by activity-guided fractionation and they were identified as eriodictyol (1), homoeriodictyol (2), dihydroquercetin (3), and luteolin (4) by spectroscopic means and displayed excellent inhibitory activity against F. graminearum and S. zeicola. Among them, luteolin (4) showed the strongest inhibitory activity with IC50 values of 56.38 and 81.48 mg L−1, to the fungi, respectively. The in vitro inhibitory activity of F. sarmentosa var. henryi (King) Corner was reported for the first time and the inhibitory action mechanism of luteolin (4) was worthy of further research.