Regulation of the Expression of Intercellular Adhesion Molecule-1 (ICAM-1) and the Putative Adhesion Molecule Basigin on Murine Cerebral Endothelial Cells by MHV-4 (JHM)

Cerebral vascular endothelial cells are integral components of the blood-brain barrier and are believed to be an important site which can restrict infection of the central nervous system by viruses and other pathogens. A potential role of cerebral vascular endothelial cells in resisting CNS infection relates to the expression of lymphocyte-endothelial adhesion molecules which could impact on the generation of anti-viral immune reactivity.