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Osteopontin is a useful predictor of bone metastasis and survival in patients with locally advanced nasopharyngeal carcinoma

Authors :
Ying Xu
Xue Hou
Xuan Wu
Jianhua Zhan
Li Zhang
Ting Zhou
Tao Qin
Yanfen Feng
Likun Chen
Rongzhen Luo
Yuxiang Ma
Pei Yu Huang
Source :
International Journal of Cancer. 137:1672-1678
Publication Year :
2015
Publisher :
Wiley, 2015.

Abstract

Bone is the most common metastatic site in nasopharyngeal carcinoma (NPC). Osteopontin (OPN) and bone sialoprotein (BSP) are demonstrated to be involved in multiple steps of distant metastasis and correlate with bone metastasis (BM) in cancers. We aim to explore the impacts of OPN and BSP on the prognosis of the patients with locally advanced NPC. A tissue microarray including 162 locally advanced NPC specimens was generated for immunohistochemical evaluation. All of the patients received curative treatment. Twenty-two patients developed BM during follow-up. The OPN expression level was higher in patients with BM than in those without BM (p = 0.005), whereas no significant difference of the BSP expression level was noted (p = 0.634). Univariate analysis demonstrated that a higher level of OPN expression associated with a poorer 8-year metastasis-free survival (MFS) rate (p

Details

ISSN :
00207136
Volume :
137
Database :
OpenAIRE
Journal :
International Journal of Cancer
Accession number :
edsair.doi...........454a0b04fe81bd10364d789fa498fa77
Full Text :
https://doi.org/10.1002/ijc.29540