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Osteopontin is a useful predictor of bone metastasis and survival in patients with locally advanced nasopharyngeal carcinoma
- Source :
- International Journal of Cancer. 137:1672-1678
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- Bone is the most common metastatic site in nasopharyngeal carcinoma (NPC). Osteopontin (OPN) and bone sialoprotein (BSP) are demonstrated to be involved in multiple steps of distant metastasis and correlate with bone metastasis (BM) in cancers. We aim to explore the impacts of OPN and BSP on the prognosis of the patients with locally advanced NPC. A tissue microarray including 162 locally advanced NPC specimens was generated for immunohistochemical evaluation. All of the patients received curative treatment. Twenty-two patients developed BM during follow-up. The OPN expression level was higher in patients with BM than in those without BM (p = 0.005), whereas no significant difference of the BSP expression level was noted (p = 0.634). Univariate analysis demonstrated that a higher level of OPN expression associated with a poorer 8-year metastasis-free survival (MFS) rate (p
- Subjects :
- Oncology
Bone sialoprotein
Cancer Research
Univariate analysis
Pathology
medicine.medical_specialty
Tissue microarray
biology
business.industry
Nasopharyngeal neoplasm
Bone metastasis
Cancer
medicine.disease
stomatognathic system
Nasopharyngeal carcinoma
Internal medicine
medicine
biology.protein
Osteopontin
business
Subjects
Details
- ISSN :
- 00207136
- Volume :
- 137
- Database :
- OpenAIRE
- Journal :
- International Journal of Cancer
- Accession number :
- edsair.doi...........454a0b04fe81bd10364d789fa498fa77
- Full Text :
- https://doi.org/10.1002/ijc.29540