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Post-GWAS multiomic functional investigation of theTNIP1locus in Alzheimer’s disease implicates mediation throughGPX3
- Publication Year :
- 2022
- Publisher :
- Cold Spring Harbor Laboratory, 2022.
-
Abstract
- The recently reportedTNIP1/GPX3locus from AD GWAS studies was investigated. Using proteomics and other functional omics data, we identified evidence for a functional mechanism linking variants in this locus to decreased CSF GPX3 levels as AD progresses, suggesting a new potential target for intervention.
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi...........4540c9c4a76202a181299cbd6d9fcc3d
- Full Text :
- https://doi.org/10.1101/2022.11.04.22277162