Toxocara Canis Increases the Potential of Breast Cancer by Reducing the Expression of the P53 Protein

Introduction:: Breast cancer is considered the most frequent type of cancer in women with high mortality worldwide, and most importantly, it is the second most common cancer. However, some breast cancer-related risk factors remain unknown. So, the current study was designed to evaluate the effect of Toxocara canis on the biomarkers correlated with proliferation, apoptosis, inflammation, and angiogenesis in 4T1 tumor-bearing mice infected with Toxocara canis for the first time. Methods:: Mice were categorized into four groups: A) control, B) treated with 4T1+ Toxocara canis, C) treated with Toxocara canis, and D) treated with 4T1. The expression of Ki-67 and P53 was then evaluated by using the immunohistochemical technique. In addition, the levels of transforming growth factor-β, Interferon gamma-γ, Interleukin 10, tumor necrosis factor-α and vascular endothelial growth factor as well as anti- Toxocara canis IgG were determined using the enzyme-linked immunosorbent assay method. objective: The current study was designed to evaluate the effect of Toxocara canis (T. canis) on the biomarkers correlated to proliferation, apoptosis, inflammation, and angiogenesis in 4T1 tumor-bearing mice infected with T. canis for the first time. Results:: The expression of Ki-67 was significantly increased in the 4T1+ Toxocara canis group than control and Toxocara canis groups (P Conclusion:: Our findings showed that Toxocara canis could probably increase the potential of breast cancer by reducing P53 in 4T1 tumor-bearing mice infected with Toxocara canis more than other groups conclusion: Our findings showed that 4T1 tumor-bearing mice infected with T. canis elevated the expression of Ki-67, VEGF, and TNF-α as well as decreased P53 and IL-10 levels. More importantly, T. canis could increase potential of breast cancer through reducing P53. other: None