Overcoming Preclinical Safety Obstacles to Discover (S)-N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor

Authors :: Christopher McBride
Lynnie Trzoss
Davide Povero
Milos Lazic
Geza Ambrus-Aikelin
Angelina Santini
Rama Pranadinata
Gretchen Bain
Ryan Stansfield
Jeffrey A. Stafford
James Veal
Ryan Takahashi
Justin Ly
Shu Chen
Liling Liu
Marika Nespi
Robert Blake
Arna Katewa
Tracy Kleinheinz
Swathi Sujatha-Bhaskar
Nandhini Ramamoorthi
Jessica Sims
Brent McKenzie
Mark Chen
Mark Ultsch
Matthew Johnson
Jeremy Murray
Claudio Ciferri
Steven T. Staben
Michael J. Townsend
Craig E. Stivala
Source :: Journal of Medicinal Chemistry. 65:14721-14739
Publication Year :: 2022
Publisher :: American Chemical Society (ACS), 2022.

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