ChemInform Abstract: Tandem Hydroboration/Reduction of Trisubstituted β,γ-Unsaturated Esters for the Asymmetric Synthesis of Chiral 1,3-Diols

Treatment of a range of trisubstituted β,γ-unsaturated esters with 2 equiv of (−)-monoisopinocampheylborane results in hydroboration of their alkene functionalities and reduction of their ester groups to afford chiral 1,3-diols containing two new vicinal β,γ-( anti )-stereocentres in 67–85% enantiomeric excess.