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Double [3 + 2] cycloadditions for diastereoselective synthesis of spirooxindole pyrrolizidines
- Source :
- Green Processing and Synthesis. 11:1128-1135
- Publication Year :
- 2022
- Publisher :
- Walter de Gruyter GmbH, 2022.
-
Abstract
- One-pot two sequential [3 + 2] cycloadditions of azomethine ylides with different dipolarophiles for diastereoselective synthesis of spirooxindole pyrrolizidines are introduced. This one-pot synthesis involving five components generates a highly condensed ring system bearing seven stereocenters diastereoselectively. The new method has high pot, atom, and step economy. Only two equivalents of water are released as a side product.
Details
- ISSN :
- 21919550
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Green Processing and Synthesis
- Accession number :
- edsair.doi...........444df9fb02fd4ab14c518fc567e2a954