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EFFECTIVENESS OF BUTYROPHENONES AND RELATED DRUGS IN NARCOTIC WITHDRAWAL IN THE RAT

EFFECTIVENESS OF BUTYROPHENONES AND RELATED DRUGS IN NARCOTIC WITHDRAWAL IN THE RAT

Authors :
Martin Dennis Hynes
Publication Year :
2020
Publisher :
University of Rhode Island, 2020.

Abstract

Narcotic dependence was established by continuous intravenous infusion of gradually increasing doses of morphine. Several days at the terminal concentration of morphine (100 mg/kg/day) was allowed prior to withdrawal. Morphine withdrawal body shakes were reliably observed upon the termination of continuous morphine infusion. The administration of morphine, methadone or _fentanyl, potent narcotic drugs, reliably abolished the occurrence of withdrawal body shakes 8 hours after the terf!lination of morphine infusion. The narcotic antagonist naloxone or pentazocine ~ad no significant effect on the rate of occurrence of withdrawal body shakes; however, there was a slight trend towards an increase in the frequency of this withdrawal index. A wide variety of neuroleptics were investigated for their ability to reduce withdrawal. The order of potency for reduction of withdrawal body shakes on a mg/kg basis for those neuroleptics tested was spiperone, benperidol, +butaclarriol, loxapine, oxiperomide, haloperidol, spiramide, chlorpromazine, trifluoperazine, pimozide and pipamperone. The dopaminergic agonists amphetamine, apomorphine and L-IX>PA were also found to dose dependently reduce withdrawal · body shakes. Azaperone, a butyrophenone possessing high alpha noradrenergic blocking potency, reduces withdrawal body shakes in a dose related manner, while the alpha adrenergic blocker phenoxybenzamine

Details

Database :
OpenAIRE
Accession number :
edsair.doi...........44352832b754915abc2b20e023409938
Full Text :
https://doi.org/10.23860/diss-hynes-martin-1978