ChemInform Abstract: Synthesis and Structure-Activity Relationships of 9-Substituted Acridines as Endothelin-A Receptor Antagonists

Authors :: Annette Marian Doherty
Kathleen M. Welch
Chet Lee
S. Klutchko
R. Thomas Winters
Xue-Min Cheng
M. A. Flynn
E. E. Reynolds
Source :: ChemInform. 28
Publication Year :: 2010
Publisher :: Wiley, 2010.
Abstract: Screening of a compound library against endothelin receptors (ETA and ETB) revealed PD 102566 (compound 1) as an ETA selective antagonist. Synthesis and structure-activity relationships (SAR) of a series of analogs are described.

Subjects :: Chemistry
Stereochemistry
cardiovascular system
Acridine derivatives
General Medicine
respiratory system
Selective antagonist
Endothelin receptor
Endothelin A Receptor Antagonists
circulatory and respiratory physiology

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