Synthesis and biodistribution of 99mTcO-TRYDTC as a novel potential tumor imaging agent

evaluated. 24 displayed high affinity for Aβ aggregates (Ki = 42 nM). The high affinity of [Tc]24 for Aβ was certified by in vitro autoradiography on brain sections of Tg and AD. Interestingly, [Tc]24 could only label Aβ in blood vessels (white triangle) but not Aβ in parenchyma (gray arrow) of the AD brain (Fig. 1). Moreover, [Tc]24 possesses moderate initial brain uptake (1.21% ID/g) and fast blood washout in normal mice, which is important for specific targeting Aβ located on the cerebrovascular vessel walls outside the BBB. The preliminary results suggest [Tc]24 is promising for detection of Aβ in CAA.