ChemInform Abstract: Indium(III) Iodide Mediated Strecker Reaction in Water: An Efficient and Environmentally Friendly Approach for the Synthesis of α-Aminonitrile via a Three-Component Condensation

A mild, efficient and environmentally friendly method has been developed for the synthesis of α-aminonitriles via a three-component condensation of aldehyde, amine and TMSCN in the presence of a catalytic amount of indium(III) iodide in water. The reactions proceeded smoothly at room temperature in water to generate the corresponding products in moderate to excellent yields.