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Platinum(terpyridine) complexes with N-heterocyclic carbene co-ligands: high antiproliferative activity and low toxicity in vivo
- Source :
- Dalton Transactions. 52:1388-1392
- Publication Year :
- 2023
- Publisher :
- Royal Society of Chemistry (RSC), 2023.
-
Abstract
- Substitution of a labile Cl− for an NHC ligand in DNA-intercalating [Pt(terpyridine)]+ complexes improved the cytotoxicity and cellular accumulation, while in vivo studies indicated good tolerability in zebrafish.
- Subjects :
- Inorganic Chemistry
Subjects
Details
- ISSN :
- 14779234 and 14779226
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Dalton Transactions
- Accession number :
- edsair.doi...........43de307e62c5394f68bdd21d6142c646
- Full Text :
- https://doi.org/10.1039/d2dt02539f