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New diterpenoid quinones derived from Salvia miltiorrhiza and their cytotoxic and neuroprotective activities
- Source :
- RSC Advances. 10:14235-14242
- Publication Year :
- 2020
- Publisher :
- Royal Society of Chemistry (RSC), 2020.
-
Abstract
- One new tanshinone derivative, which possesses an unusual 6/6/5/6 fused-ring skeleton system (1), together with four new five-membered lactone benzohexa-membered ring compounds (2, 3, 4A and 4B), and three new carboxyl substituted 5,5-spiroketal compounds (5–7), were isolated from the dried rhizomes of Salvia miltiorrhiza. The structures of these compounds were determined by multiple spectral analyses (UV, IR, NMR, and HR-ESI-MS). In addition, the absolute configurations were established by X-ray diffraction experiments, calculated and experimental circular dichroism spectra. Evaluation of antitumor activity showed that 1 had strong cytotoxicity to tumor-repopulating cells (TRCs) with an IC50 value of 2.83 μM. In the evaluation of neuroprotective activity, 4A and 6 showed a strong improvement in the survival rates of SK-N-SH cell injury induced by oxygen glucose deprivation (OGD).
- Subjects :
- chemistry.chemical_classification
010405 organic chemistry
Stereochemistry
General Chemical Engineering
General Chemistry
010402 general chemistry
01 natural sciences
Salvia miltiorrhiza
Neuroprotection
Terpenoid
0104 chemical sciences
Rhizome
chemistry.chemical_compound
chemistry
Cytotoxicity
IC50
Derivative (chemistry)
Lactone
Subjects
Details
- ISSN :
- 20462069
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- RSC Advances
- Accession number :
- edsair.doi...........43d0a53afd09a54237797a5f703f6e53