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The comparison of the chronic-phase vascular healing between bioabsorbable and durable polymer drug eluting stent by using optical coherence tomography

Authors :
S Kimura
M Ohmori
H Fujii
M Suzuki
R Tateishi
Tetsuo Sasano
M Shimizu
T Kaneda
Y Yamakami
K Hara
H Shimada
T Manno
Ami Isshiki
Source :
European Heart Journal. 41
Publication Year :
2020
Publisher :
Oxford University Press (OUP), 2020.

Abstract

Background Bioabsorbable polymer drug eluting stents (BP-DESs) were designed to reduce a vascular inflammatory reaction compared to durable polymer drug eluting stents (DP-DESs). However, few studies have compared vascular responses to BP-DESs and DP-DESs. Methods We enrolled 88 consecutive patients with single culprit coronary artery lesions (31 lesions with acute coronary syndrome) undergoing a single stent-implantation. BP-DESs and DP-DESs were implanted in 50 (57%) and 38 patients (43%), respectively. All lesions underwent optical coherence tomography examination at chronic phase and intrastent OCT findings at the follow-up were evaluated in every 1-mm cross-sections (CSs). Results A total of 1887 CSs (BP-DES: 1096, DP-DES: 791) were analyzed. The median period of follow-up OCT was 293 (250–374) days. There were no differences in the patient, lesion, and initial clinical presentation of acute coronary syndrome (ACS). BP-DESs had significantly higher percent neointimal hyperplasia area, defined as neointimal hyperplasia area divided by stent area x 100 (18.4±9.0% vs. 16.1±9.9%, p Conclusion BP-DESs showed homogenous neointimal growth and complete stent coverage quantitatively. Meanwhile, the significant relationships of BP-DES with LIN may suggest that the neointimal quality remains immature in BP-DESs in this period. Funding Acknowledgement Type of funding source: None

Details

ISSN :
15229645 and 0195668X
Volume :
41
Database :
OpenAIRE
Journal :
European Heart Journal
Accession number :
edsair.doi...........439a864e027b4564f52a84948a8cd892
Full Text :
https://doi.org/10.1093/ehjci/ehaa946.2472