ChemInform Abstract: Synthesis of Spiro[indoline-3,2′-quinoline] Derivatives Through a Four-Component Reaction

An efficient synthetic procedure for the synthesis of functionalized tetrahydrospiro[indoline-3,2′-quinoline] derivatives was successfully developed and involves the four-component reaction of arylamines, dimethyl acetylenedicarboxylate, isatins, and a cyclohexane-1,3-dione in acetic acid. The advantages of this reaction include the use of common starting materials and mild reaction conditions and it is operationally simple.