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Antioxidants up-regulate PPAR$gamma; and decrease fibrosis in chronic pancreatitis

Authors :
Richard A. Prinz
Robert J. Walter
Archana Verma
Bashar M Attar
Mary Jo Atten
Paolo Gattuso
K. J. M. Liu
Source :
The American Journal of Gastroenterology. 98:S64
Publication Year :
2003
Publisher :
Ovid Technologies (Wolters Kluwer Health), 2003.

Abstract

Purpose: Pancreatic fibrosis results from repeated episodes of inflammation and chronic oxidative stress within the pancreas. PPAR is a ligand-activated transcription factor that modulates inflammation in different tissues, and has been shown to block activation of pancreatic stellate cells in vitro.The aim of this study was to investigate the antifibrotic/anti-inflammatory effect of the antioxidants, vitamin C and vitamin E, in chronic pancreatitis.

Details

ISSN :
00029270
Volume :
98
Database :
OpenAIRE
Journal :
The American Journal of Gastroenterology
Accession number :
edsair.doi...........43096bf0bfbddb875e116ef1cf91751d
Full Text :
https://doi.org/10.1016/s0002-9270(03)00954-7