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Response profiles to amino acid odorants of olfactory glomeruli in larvalXenopus laevis
- Source :
- The Journal of Physiology. 581:567-579
- Publication Year :
- 2007
- Publisher :
- Wiley, 2007.
-
Abstract
- Glomeruli in the vertebrate olfactory bulb (OB) appear as anatomically discrete modules receiving direct input from the olfactory epithelium (OE) via axons of olfactory receptor neurons (ORNs). The response profiles with respect to amino acids (AAs) of a large number of ORNs in larval Xenopus laevis have been recently determined and analysed. Here we report on Ca2+ imaging experiments in a nose–brain preparation of the same species at the same developmental stages. We recorded responses to AAs of glomeruli in the OB and determined the response profiles to AAs of individual glomeruli. We describe the general features of AA-responsive glomeruli and compare their response profiles to AAs with those of ORNs obtained in our previous study. A large number of past studies have focused either on odorant responses in the OE or on odorant-induced responses in the OB. However, a thorough comparison of odorant-induced responses of both stages, ORNs and glomeruli of the same species is as yet lacking. The glomerular response profiles reported herein markedly differ from the previously obtained response profiles of ORNs in that glomeruli clearly have narrower selectivity profiles than ORNs. We discuss possible explanations for the different selectivity profiles of glomeruli and ORNs in the context of the development of the olfactory map.
- Subjects :
- medicine.medical_specialty
Physiology
Xenopus
Context (language use)
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
030304 developmental biology
chemistry.chemical_classification
0303 health sciences
Larva
Olfactory receptor
biology
urogenital system
fungi
respiratory system
biology.organism_classification
Olfactory bulb
Amino acid
Cell biology
medicine.anatomical_structure
Endocrinology
chemistry
sense organs
Olfactory epithelium
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 00223751
- Volume :
- 581
- Database :
- OpenAIRE
- Journal :
- The Journal of Physiology
- Accession number :
- edsair.doi...........42e951b5c28750fab65293a67e135534