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Prostate Biopsy Processing: An Innovative Model for Reducing Cost, Decreasing Test Time, and Improving Diagnostic Material
- Source :
- American Journal of Clinical Pathology. 152:757-765
- Publication Year :
- 2019
- Publisher :
- Oxford University Press (OUP), 2019.
-
Abstract
- Objectives Current protocols for processing multiple prostate biopsy cores per case are uneconomical and cumbersome. Tissue fragmentation and loss compromise cancer diagnosis. We sought to study an alternate method to improve processing and diagnosis of prostate cancer. Methods Two sets of sextant biopsy specimens from near-identical locations were obtained ex vivo from 48 prostate specimens. One set was processed in the standard fashion while the other was processed using the BxChip, a proprietary biomimetic matrix that accommodates six cores on a single chip. Parameters including grossing, embedding, sectioning and reading time, length of tissue, and degree of fragmentation were compared. Results A significant reduction (more than threefold) in preanalytical and analytical time was observed using the multiplex method. Nonlinear fragmentation was absent, in contrast to standard processing. Conclusions The BxChip reduced tissue fragmentation and increased efficiency of prostate biopsy diagnosis. It also resulted in overall cost savings and significantly increased tissue length.
- Subjects :
- medicine.medical_specialty
Prostate biopsy
medicine.diagnostic_test
business.industry
030232 urology & nephrology
Cancer
General Medicine
medicine.disease
03 medical and health sciences
Prostate cancer
0302 clinical medicine
medicine.anatomical_structure
Prostate
030220 oncology & carcinogenesis
Biopsy
Medicine
Multiplex
Radiology
Fragmentation (cell biology)
business
Ex vivo
Subjects
Details
- ISSN :
- 19437722 and 00029173
- Volume :
- 152
- Database :
- OpenAIRE
- Journal :
- American Journal of Clinical Pathology
- Accession number :
- edsair.doi...........4258be968dd0eea0437203e248265dba