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Adsorption of ibuprofen enantiomers on a chiral stationary phase with a grafted antibiotic eremomycin

Authors :
Leonid Asnin
E. N. Reshetova
Source :
Russian Journal of Physical Chemistry A. 89:275-281
Publication Year :
2014
Publisher :
Pleiades Publishing Ltd, 2014.

Abstract

The adsorption of ibuprofen enantiomers on a chiral stationary phase Nautilus-E with a grafted antibiotic eremomycin from aqueous ethanol acetate buffer solutions was studied by chromatography. The ethanol concentration in the mobile phase was varied from 40 to 60 vol %. The adsorption isotherms of both enantiomers had a complex shape characterized by non-Langmuir type curvature and the presence of an inflection point. This is explained by two factors: the energy heterogeneity of the surface of the stationary phase and the dissociation of ibuprofen in the liquid phase. The effect of the system peak on the shape of the chromatograms of the target component was investigated. The temperature effect on the adsorption equilibrium was discussed.

Details

ISSN :
1531863X and 00360244
Volume :
89
Database :
OpenAIRE
Journal :
Russian Journal of Physical Chemistry A
Accession number :
edsair.doi...........41dd12decf08f132d3d8f3bcdd0645a4
Full Text :
https://doi.org/10.1134/s0036024415020259